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Maze procedure: A therapeutic procedure that isolates a part of the heart that is responsible for the origination of an arrhythmia. In a surgical maze procedure, a surgeon incises a line or lines in the cardiac tissue to create a barrier between the source of an arrhythmia and the rest of the heart. In a catheter maze procedure, a physician (most often an electrophysiologist) "burns" a line or lines in a heart chamber with a radiofrequency therapeutic catheter.